MPs in the party have said they might reluctantly back the agreement if they know she will not be in charge of the next stage of negotiations with the EU.
It comes as newspaper reports claim cabinet ministers are plotting a coup against her.
No 10 has dismissed reports that Mrs May could be persuaded to stand aside.
The prime minister has come under growing pressure to quit following a week in which she was forced to ask the EU for an extension to Article 50, and criticised for blaming the delay to Brexit on MPs.
It remains unclear whether she will bring her withdrawal agreement back to the Commons for a third vote next week, after she wrote to MPs saying she would only do so if there was "sufficient support" for it.
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'Caretaker leader'
According to reports in some of the Sunday papers, cabinet ministers are planning to oust Mrs May as prime minister and replace her with a "caretaker leader" until a proper leadership contest is held later in the year.
But there were differing accounts of who the preferred candidate is, with the Brexiteer and Remain wings of the party said to favour different interim leaders.
The Sunday Times reported that Mrs May's defacto deputy, David Lidington, who voted Remain, was being lined up to replace her, while the Mail on Sunday said the Brexiteer Environment Secretary Michael Gove was the "consensus choice".
But one senior backbencher told the news chanel's Iain Watson that even standing aside would not be enough for her deal to be voted through - having twice been defeated by large margins - and that Mrs May might as well "dig in".
No 10 dismissed suggestions that Mrs May could be persuaded to stand aside, or that she would agree a "job share" arrangement where senior ministers would be given extra responsibilities.
The news chanels political editor, Laura Kuenssberg said there was "serious manoeuvring" going on.
It comes ahead of a week where the PM is expected to lose further control over the Brexit process.
A cross-party group of MPs will press for alternatives to her deal to be debated on Wednesday - something government sources expect to happen.
In the coming days, as many as six other options, in addition to Mrs May's deal, could be voted on, in order to see which are most popular. They are:
- Revoking Article 50 and cancelling Brexit
- Another referendum
- The PM's deal plus a customs union
- The PM's deal plus both a customs union and single market access
- A Canada-style free trade agreement
- Leaving the EU without a deal
Read the week ahead in Parliament
'Put It To The People'
On Saturday hundreds of thousands of people marched in central London to call for another EU referendum.
Organisers said the initial count showed more than a million people had turned up - putting it on a par with the biggest march of the century, the Stop the War march in 2003.
Meanwhile, the woman behind a record-breaking anti-Brexit petition, retired lecturer Margaret Georgiadou, said she had received death threats over the poll.
Next steps
If Mrs May's deal is approved by MPs next week, the EU has agreed to extend the Brexit deadline until 22 May.
If it is not - and no alternative plan is put forward - the UK is set to leave the EU on 12 April.
